Background: It is known that patients with spinocerebellar ataxia (SCA) tend to exhibit depressive symptoms.But the pathology of depressive symptoms complicated with SCA, including the reaction to the stress resulting from decreased motor function and central dysfunction due to neurodegeneration, is controversial and remains to be elucidated.To our
Statins are 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors widely used in the treatment of hyperlipidemia.The inhibition of HMG-CoA reductase in the mevalonate pathway leads to the suppression of cell proliferation and induction of apoptosis.The cyclic GMP-AMP synthase (cGAS) stimulator of the interferon genes (STING) signalin
Abstract Background Giant cell arteritis (GCA) is frequently associated with aortic involvement that is likely to cause life-threatening structural complications (aneurysm, dissection).Few studies have investigated the occurrence of these complications, and no predictive factor has been identified so far.The aim of this study was to investigate fac
The dominant approach to decision-making in public health policy for infectious diseases relies heavily on expert opinion, which often applies empirical evidence to policy questions in a manner that is neither systematic nor transparent.Although systematic reviews are frequently commissioned to inform specific components of policy (such as efficacy
Introduction Cancer remains a major global health challenge, affecting millions annually and ranking as the second leading cause of death worldwide.The complexity of cancer treatment requires an interdisciplinary approach, connecting professionals from various fields to deliver personalised and integrated care.However, structural issues and insuffi